The conventional wisdom is that common genetic variations have only a very small impact on mortality and health across the majority of the present human life span, but as the molecular damage of aging accumulates in later life, a time of frailty, disability, and high risk of age-related disease, genes make an increasingly significant contribution to determining remaining life expectancy. Here is a very readable open access paper on this topic, covering at a high level a range of the mainstream work on genetics, lifestyle, and aging from the past few decades:
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