Low doses of lithium have been shown to modestly extend life in nematodes, and a Japanese study suggested a correlation between human life expectancy and natural variations in lithium in tap water - a small and uncertain effect, as are most when it comes to human longevity. So it is interesting to find a similar outcome in flies, and here researchers have linked the effects of lithium intake to genes that are already targets of interest in aging research, NRF-2 and GSK-3, involved in regulation of cellular responses to stresses:
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